As the U.S. Court of Appeals for the Federal Circuit convenes its October 2025 session, several pivotal cases are set to be argued, each carrying significant implications for patent law and intellectual property rights. Below is an overview of four notable disputes to watch:
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Seagen Inc. v. Daiichi Sankyo Co., Ltd.
Seagen Inc. secured a nearly $42 million patent infringement verdict against Daiichi Sankyo Co., Ltd. However, the validity of Seagen’s patent was subsequently challenged and invalidated in a post-grant review proceeding. The Federal Circuit will now determine whether the initial jury award stands in light of the patent’s invalidation, addressing the complex interplay between jury verdicts and administrative patent reviews.
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Regenxbio Inc. v. Sarepta Therapeutics, Inc.
Regenxbio Inc. is appealing the invalidation of its gene therapy patent, which was deemed to cover a natural phenomenon and thus unpatentable. The case centers on the boundaries of patent eligibility for biotechnological innovations, particularly concerning naturally occurring genetic material. The Federal Circuit’s decision could have far-reaching effects on the biotech industry’s approach to patenting gene-based therapies.
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Ingenico Inc. et al. v. IOENGINE, LLC
In May 2025, the Federal Circuit addressed the scope of inter partes review (IPR) estoppel in this case. The court ruled that IPR estoppel under 35 U.S.C. § 315(e)(2) applies only to invalidity grounds based on patents or printed publications that were raised or could have been raised during the IPR. This decision clarified that estoppel does not extend to invalidity claims based on product prior art or evidence of public use, which are outside the scope of IPR proceedings. The ruling has significant implications for how defendants can challenge patent validity in district courts following IPR decisions. ([reuters.com](https://www.reuters.com/legal/legalindustry/federal-circuit-resolves-district-court-split-scope-estoppel-after-patent-ipr-2025-07-01/?utm_source=openai))
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V.O.S. Selections, Inc. v. United States
This case involves a dispute over the U.S. government’s authority to impose tariffs on imported goods. V.O.S. Selections, Inc. challenges the legality of certain tariffs imposed by the Trump administration, arguing that they were enacted without proper statutory authority. The Federal Circuit’s decision will address the extent of executive power in trade policy and could influence future tariff implementations. ([supremecourt.gov](https://www.supremecourt.gov/docket/docketfiles/html/public/25-250.html?utm_source=openai))
These cases underscore the Federal Circuit’s critical role in shaping patent law and intellectual property rights. Legal professionals and industry stakeholders should closely monitor the outcomes, as they are likely to influence litigation strategies and innovation policies in the coming years.